Explore with Light

Welcome to Skylight Discovery, where innovation meets precision. We are experts in drug discovery, specializing in proprietary conformational change measurements for conventional and challenging targets

Technology

Our cutting-edge optical technology ensures targets are fully functional and dynamic, enabling precise measurement of ligand-induced conformational changes and providing crucial insights for drug development. We are motivated to help discover medicines for a range of targets, including 'undruggable' targets such as protein-protein interactions.

Our tools empower drug discovery scientists to make informed decisions and accelerate their research. Skylight's technology can rapidly identify leads with allosteric mechanisms of action and druggable, cryptic pockets.

Our Offerings

Ranging from hit finding and validation to lead optimization

Assay development

Test tool ligands and compounds

Screening

High-throughput screening for conformational drug discovery

Hit to Lead

Determine mechanism of action, validate hits, refine leads

About Us

Our Focus

Skylight offers its proprietary conformational change measurement technology to quickly identify ligands with unique mechanisms of action. If you have a project that you think we could help with, please get in touch.

Skylight is founded by Joshua Salafsky, who invented the company's technology, and previously founded two venture-backed companies, Biodesy and Quanta Therapeutics.